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The risk of subclinical carotid atherosclerosis in patients with chronic hepatitis C
Introduction:
The role of hepatitis C virus in the pathogenesis of atherosclerotic disease has been suggested by several studies.
Aim:
To assess the association between subclinical carotid atherosclerosis and chronic hepatitis C.
Methods:
40 patients infected with chronic hepatitis C and 40 control cases were evaluated by anthropometric and metabolic measurements. The risk of subclinical atherosclerosis was assessed by ultrasound measurement of carotid intima-media thickness. A high cardiovascular risk atherosclerosis was defined by carotid intima-media thickness > 75th percentile.
Results:
The carotid intima-media thickness and the prevalence of high cardiovascular risk atherosclerosis were significantly higher in the group infected with hepatitis C compared to the control group (0.68 VS 0.60, p=0.02) and (82.5% vs. 40%; 0.001) respectively. In multivariate studies, activity ≥ A2 and age> 40 years were the independent factors associated with the carotid intima-media thickness and hepatitis C was the only independent factor associated with high cardiovascular risk atherosclerosis (OR=4.81 CI at 95%: 1.6-14.42).
Conclusions:
In our study, chronic hepatitis C was associated with a high risk of carotid atherosclerosis.
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