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Related Experiment Video

Updated: Oct 1, 2025

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

Published on: January 21, 2020

Viruses, periodontitis, and comorbidities.

Flavia Teles¹, Ronald G Collman², Dana Mominkhan³

¹Department of Basic and Translational Sciences, School of Dental Medicine, Center for Innovation & Precision Dentistry, School of Dental Medicine & School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Periodontology 2000

|March 4, 2022

Summary

Periodontal diseases may impact systemic health, not just through bacteria, but also via viruses. This review examines the role of oral viruses in linking periodontal and systemic conditions, offering new insights for patient management.

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Determination of Biofilm Initiation on Virus-infected Cells by Bacteria and Fungi

Determination of Biofilm Initiation on Virus-infected Cells by Bacteria and Fungi

Published on: July 6, 2016

Area of Science:

Periodontal Medicine
Oral Microbiology
Infectious Diseases

Background:

Established links between periodontal diseases and systemic conditions (e.g., cardiovascular disease, adverse pregnancy outcomes, cancer) were primarily attributed to bacterial factors.
The field of periodontal medicine has explored the impact of oral pathogens on overall health, focusing on bacterial mechanisms.
Emerging evidence suggests other oral microorganisms, such as viruses, may also play a significant role in these connections.

Purpose of the Study:

To review current knowledge on the role of viruses in connecting periodontal diseases with systemic conditions.
To explore the mechanistic basis for these viral associations.
To highlight the clinical implications for patient management and treatment.

Main Methods:

Comprehensive literature review of studies investigating the interplay between oral viruses, periodontal disease, and systemic health.
Analysis of proposed pathogenetic mechanisms involving viral infections, inflammation, and immune modulation.
Synthesis of findings to understand the broader implications for periodontal medicine.

Main Results:

Human viruses are ubiquitous in the oral cavity and associated with periodontal diseases.
Viruses can elicit inflammatory responses, compromise immunity, and interact with bacteria, potentially exacerbating disease.
Evidence supports a plausible role for viruses in the pathogenesis of systemic conditions linked to periodontal disease.

Conclusions:

Viruses represent a significant, yet often overlooked, factor in the relationship between periodontal health and systemic diseases.
Understanding viral contributions is crucial for a comprehensive approach to periodontal medicine.
Future research and clinical strategies should consider the impact of oral viral infections on systemic health outcomes.