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Updated: Oct 1, 2025
07:15
Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
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Periodontitis and coronavirus disease 2019
Faleh Tamimi1, Shiraz Altigani1, Mariano Sanz2
1College of Dental Medicine, QU Health, Qatar University, Doha, Qatar.
Periodontology 2000
|March 4, 2022
Summary
Periodontitis may worsen outcomes for patients with coronavirus disease 2019 (COVID-19). This link may be due to inflammation and bacteria from gum disease affecting lung infections and immune responses to SARS-CoV-2.
Area of Science:
- Oral Health and Infectious Diseases
- Immunology and Systemic Inflammation
Background:
- Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, can range from mild to severe, necessitating understanding of risk factors for poor outcomes.
- Periodontitis, a gum disease, shares characteristics with COVID-19, including systemic inflammation and coagulation pathway alterations.
- Common confounding factors like diabetes, hypertension, and obesity are associated with both conditions, suggesting a potential link.
Purpose of the Study:
- To review and evaluate the scientific evidence connecting COVID-19 and periodontitis.
- To explore the potential underlying biological mechanisms linking these two conditions.
Main Methods:
- Systematic review of existing scientific literature.
- Analysis of studies investigating oral manifestations of COVID-19.
- Examination of research on the association between periodontitis and COVID-19 severity.
Main Results:
- COVID-19 can present with oral symptoms and affect periodontal tissues.
- Some studies indicate a correlation between periodontitis and increased COVID-19 severity.
- Periodontal bacteria may directly exacerbate lung infections, and periodontitis can promote systemic inflammation.
Conclusions:
- Periodontitis may increase the risk of severe COVID-19 outcomes.
- Mechanisms include direct bacterial effects and indirect systemic inflammation.
- Further research is required to confirm these findings and explore the role of periodontal care in managing COVID-19.
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