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GPER-dependent estrogen signaling increases cardiac GCN5L1 expression

Janet R Manning1,2,3, Dharendra Thapa1,2,3, Manling Zhang1,2,3

  • 1Division of Cardiology, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.

American Journal of Physiology. Heart and Circulatory Physiology
|March 4, 2022
PubMed
Summary

Female hearts show higher mitochondrial protein acetylation due to increased GCN5L1 levels, mediated by estrogen via G protein-coupled estrogen receptor (GPER) activation. This reveals a key factor in sex-based differences in cardiac metabolism.

Keywords:
GCN5L1GPERSIRT3acetylationestrogen

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