[Breast carcinoma with giant cell stromal reaction. First male case]

We report here the first case, to our knowledge, of mammary carcinoma with giant-cell stromal reaction occurring in a man. Review of literature allows to consider this carcinoma as a distinctive morphological entity. Ultrastructural cytochemical and immunohistochemical studies show that giant cells also present in metastases are non tumorous cells coming from mononuclear phagocytes cells system. This entity is peculiar by presence of inusually high titers of receptors to progesterone. Clinical evolution is still not well known.