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The Sickle Cell Disease Functional Assessment (SCD-FA) tool: a feasibility pilot study.
Charity I Oyedeji1,2,3, Katherine Hall4,5,6, Alison Luciano4
1Department of Medicine, Division of Hematology, Duke University School of Medicine, Durham, NC, USA. charity.oyedeji@duke.edu.
Pilot and Feasibility Studies
|March 5, 2022
Summary
The Sickle Cell Disease Functional Assessment (SCD-FA) is a feasible and safe tool for evaluating functional decline in adults with sickle cell disease (SCD). It effectively identifies physical impairments, aiding in risk assessment for older adults with SCD.
Area of Science:
- Geriatrics
- Hematology
- Clinical Assessment
Background:
- Life expectancy for sickle cell disease (SCD) patients has increased, leading to geriatric-like complications.
- No dedicated instruments exist to measure functional decline or age in adults with SCD.
- This study aimed to assess the feasibility of the Sickle Cell Disease Functional Assessment (SCD-FA).
Purpose of the Study:
- To evaluate the feasibility of the Sickle Cell Disease Functional Assessment (SCD-FA).
- To assess the safety and acceptability of the SCD-FA in adults with SCD.
- To identify functional impairments in adults with SCD using the SCD-FA.
Main Methods:
- 40 adults with SCD (18-49 and 50+ years) were enrolled in a prospective cohort study.
- The SCD-FA included validated geriatric oncology measures and additional physical, cognitive, and patient-reported assessments.
- Primary outcome was assessment completion proportion; secondary outcomes included consent, duration, acceptability, and adverse events.
Main Results:
- 91% of participants completed the SCD-FA, with a median duration of 89 minutes.
- The assessment was deemed acceptable, with no adverse events reported.
- Exploratory analysis revealed 63% of participants had slow usual gait speed, indicating functional impairment.
Conclusions:
- The SCD-FA is a feasible, acceptable, and safe tool for adults with SCD.
- Physical performance tests within the SCD-FA identified significant functional impairments.
- Future research will validate the SCD-FA's ability to predict patient-important outcomes.
Keywords:
AgingFrailtyFunctional assessmentGait speedGeriatric assessmentGeriatricsOlder adultsSickle cell disease
