Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Continuation therapy with amitriptyline in depression.

A Coppen, K Ghose, S Montgomery

    The British Journal of Psychiatry : the Journal of Mental Science
    |July 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Geographical variation and area-level socioeconomic disadvantage in recognized depression: A nationwide register-based Danish cohort study.

    Social psychiatry and psychiatric epidemiology·2026
    Same author

    Light Chain Deposition Disease - presenting with Cystic Pulmonary Disorder as primary manifestation - A case report.

    Respiratory medicine case reports·2026
    Same author

    Sex-specifics of ECT outcome.

    Journal of affective disorders·2023
    Same author

    Influence of Nodal signalling on pluripotency factor expression, tumour cell proliferation and cisplatin-sensitivity in testicular germ cell tumours.

    BMC cancer·2020
    Same author

    Dysregulation of FGFR signalling by a selective inhibitor reduces germ cell survival in human fetal gonads of both sexes and alters the somatic niche in fetal testes.

    Human reproduction (Oxford, England)·2019
    Same author

    Positive association between cholesterol in human seminal plasma and sperm counts: results from a cross-sectional cohort study and immunohistochemical investigations.

    Andrology·2018
    Same journal

    The pressurised leaky funnel: rethinking recruitment, selection and retention in the UK psychiatry workforce.

    The British journal of psychiatry : the journal of mental science·2026
    Same journal

    Cutting through stigma: psychiatry and neurosurgery working together.

    The British journal of psychiatry : the journal of mental science·2026
    Same journal

    A fourth pillar for evidence-based medicine: implications for psychiatry - CORRIGENDUM.

    The British journal of psychiatry : the journal of mental science·2026
    Same journal

    Understanding negative perceptions of psychiatrists on social media: lessons from public discourse and professional self-reflection.

    The British journal of psychiatry : the journal of mental science·2026
    Same journal

    Attachment-informed psychopharmacology in psychiatric care.

    The British journal of psychiatry : the journal of mental science·2026
    Same journal

    Acceptability and accuracy of point-of-care monitoring of lithium levels.

    The British journal of psychiatry : the journal of mental science·2026
    See all related articles

    Continuing antidepressant medication, such as amitriptyline, for eight months after recovery significantly reduces relapse rates in patients with depressive illness. Ensuring patient compliance is crucial for maintaining treatment efficacy.

    Area of Science:

    • Psychiatry and Clinical Psychology
    • Pharmacology and Therapeutics

    Background:

    • Depressive illness management often involves antidepressant medication.
    • Long-term treatment strategies for maintaining remission require further investigation.
    • Amitriptyline is a commonly prescribed tricyclic antidepressant.

    Purpose of the Study:

    • To evaluate the efficacy of continued amitriptyline treatment in preventing relapse in patients with depressive illness.
    • To assess the impact of patient compliance on treatment outcomes.
    • To determine the optimal duration for maintenance antidepressant therapy.

    Main Methods:

    • Thirty-two patients who responded to amitriptyline (150 mg daily) were randomized to receive either placebo or continued amitriptyline for one year.
    • Plasma amitriptyline concentrations were monitored.

    Related Experiment Videos

  • Relapse rates and patient compliance were recorded.

    • Main Results:

    • None of the patients who continued amitriptyline treatment relapsed.
    • Five out of sixteen patients (31.25%) in the placebo group relapsed.
    • No correlation was found between plasma amitriptyline concentration and residual affective morbidity.
    • Three patients who did not adhere to the prescribed amitriptyline regimen relapsed.

    Conclusions:

    • Continued treatment with amitriptyline for eight months post-recovery is effective in preventing relapse in responders.
    • Patient compliance is a critical factor in maintaining remission.
    • Maintenance antidepressant therapy is recommended for selected patients with depressive illness.