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Targeting Microbial Bio-film: an Update on MDR Gram-Negative Bio-film Producers Causing Catheter-Associated Urinary

Susmita Chakrabarty1, Monali P Mishra2, Dipankar Bhattacharyay3

  • 1School of Paramedics and Allied Health Sciences, Centurion University of Technology and Management, Sitapur, Odisha, India.

Applied Biochemistry and Biotechnology
|March 5, 2022
PubMed

Insights

Urinary tract infections (UTIs) often recur due to biofilm-producing, multidrug-resistant (MDR) Gram-negative bacteria. This review explores their mechanisms, challenges in treating catheter-associated UTIs, and potential anti-biofilm therapies.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Urology

Background:

  • Urinary tract infections (UTIs) are a significant cause of recurrent infectious disease across all age groups.
  • Bacterial biofilms play a crucial role in the pathogenesis of UTIs, leading to persistent infections, recurrences, and relapses.
  • Catheter-associated UTIs (CAUTIs) represent a major challenge in healthcare settings.

Purpose of the Study:

  • To review the role and mechanisms of biofilm-producing multidrug-resistant (MDR) Gram-negative bacteria in causing UTIs.
  • To highlight the significance of these bacteria and the challenges in treating and preventing CAUTIs.
  • To explore novel strategies targeting biofilms and discuss phytochemicals with anti-biofilm activity.

Main Methods:

  • Literature review focusing on biofilm formation by uropathogenic bacteria.
  • Analysis of MDR Gram-negative bacteria associated with UTIs and CAUTIs.
  • Compilation of data on anti-biofilm approaches and phytochemical interventions.

Main Results:

  • Biofilm production by MDR Gram-negative bacteria is a key factor in recurrent and persistent UTIs, particularly CAUTIs.
  • Understanding biofilm mechanisms is essential for developing effective treatment and prevention strategies.
  • Phytochemicals show promise as potential agents against biofilm formation.

Conclusions:

  • Targeting bacterial biofilms is critical for managing recurrent UTIs and CAUTIs.
  • Further research into anti-biofilm therapies, including phytochemicals, is warranted.
  • Effective control of biofilm-producing uropathogenic bacteria is necessary to improve patient outcomes.
Keywords:
Acinetobacter baumanniiAntibiotic resistanceBio-filmCAUTIEscherichia coliPseudomonas aeruginosa

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