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Related Concept Videos

Drugs for Treatment of Ulcerative Colitis in IBD01:29

Drugs for Treatment of Ulcerative Colitis in IBD

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Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
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Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

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Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
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Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
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Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
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Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
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Drugs for Peptic Ulcer Disease: Sucralfate as Mucosal Protective Agents01:24

Drugs for Peptic Ulcer Disease: Sucralfate as Mucosal Protective Agents

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In the intricate landscape of the gastric lumen, excessive acid secretion disrupts the natural defense mechanisms, weakening the mucus-bicarbonate barrier. This vulnerability allows pepsin to infiltrate epithelial cells, digesting mucosal proteins and triggering erosion, leading to ulcer formation.
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Related Experiment Video

Updated: Oct 1, 2025

Neuro-rehabilitation Approach for Sudden Sensorineural Hearing Loss
09:44

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Sensorineural hearing loss and ulcerative colitis in remission.

Vishal Bodh1, Rajesh Kumar1, Rajesh Sharma1

  • 1Department of Gastroenterology, Indira Gandhi Medical College, Shimla, 171 001, India.

Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology
|March 5, 2022
PubMed
Summary

This study found no significant difference in sensorineural hearing loss (SNHL) between patients with inflammatory bowel disease-ulcerative colitis (IBD-UC) in remission and healthy controls. Further research is needed to understand the SNHL and IBD connection.

Keywords:
Autoimmune diseaseCrohn diseaseExtraintestinal manifestationInflammatory bowel diseaseMayo scoreMontreal classificationOtoscopyPure tone audiometrySensorineural hearing lossTympanometryUlcerative colitis

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Area of Science:

  • Otolaryngology
  • Gastroenterology
  • Audiology

Background:

  • Sensorineural hearing loss (SNHL) is an underreported extraintestinal manifestation of inflammatory bowel disease (IBD).
  • Investigating the association between SNHL and IBD-ulcerative colitis (IBD-UC) in remission is crucial for comprehensive patient care.

Purpose of the Study:

  • To compare the prevalence and severity of SNHL in patients with IBD-UC in remission against a control group.
  • To determine if a statistically significant association exists between SNHL and IBD-UC in remission.

Main Methods:

  • A prospective observational study involving 50 IBD-UC patients in remission and 50 healthy controls.
  • Comprehensive audiological assessments including otoscopy, tympanometry, and pure tone audiometry (PTA).
  • Systemic and ear, nose, and throat (ENT) examinations were conducted for all participants.

Main Results:

  • No significant demographic differences were observed between the IBD-UC and control groups.
  • Otoscopy and tympanometry results were normal in all participants.
  • Pure tone audiometry revealed no statistically significant difference in the frequency, severity, or distribution (unilateral/bilateral) of SNHL between the groups.

Conclusions:

  • There is no statistically significant difference in SNHL frequency or severity between ulcerative colitis patients in remission and age- and sex-matched healthy controls.
  • The findings suggest that SNHL may not be a common or significant extraintestinal manifestation in patients with quiescent ulcerative colitis.