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Long noncoding RNA SNHG17: a novel molecule in human cancers

Li Ma1, Jin Gao1, Niu Zhang1

  • 1Cancer Medical Center, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, 210011, Jiangsu, China.

Cancer Cell International
|March 6, 2022
PubMed

Insights

Small nucleolar RNA host gene 17 (SNHG17) is a novel long non-coding RNA (lncRNA) implicated in various cancers. This review explores SNHG17

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • Long non-coding RNAs (lncRNAs) are increasingly recognized for their roles in disease pathogenesis.
  • Dysregulation of lncRNAs is a common feature in various human cancers.
  • Small nucleolar RNA host gene 17 (SNHG17) is an emerging lncRNA associated with oncogenic functions.

Purpose of the Study:

  • To review and summarize current research on the biological functions of SNHG17.
  • To discuss the potential clinical applications of SNHG17 in cancer diagnosis and treatment.
  • To highlight the oncogenic roles of SNHG17 in tumor progression.

Main Methods:

  • Literature review of studies investigating SNHG17.
  • Analysis of research on SNHG17's involvement in cancer cell proliferation, migration, and invasion.
  • Examination of studies on SNHG17's association with apoptosis and drug resistance.

Main Results:

  • SNHG17 is highly expressed in numerous tumor types.
  • SNHG17 influences key cancer cell behaviors including proliferation, migration, invasion, and apoptosis.
  • Elevated SNHG17 expression correlates with poor clinical prognosis and chemoresistance.

Conclusions:

  • SNHG17 plays a significant role in cancer development and progression.
  • SNHG17 holds promise as a potential biomarker for cancer prognosis.
  • Targeting SNHG17 may offer novel therapeutic strategies for cancer treatment.
Keywords:
CancerDiagnosisGene regulationPrognosisSNHG17lncRNA

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