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Lipid based nanoparticles as a novel treatment modality for hepatocellular carcinoma: a comprehensive review on

Khaled Mahmoud1,2, Shady Swidan3,4, Mohamed El-Nabarawi5

  • 1Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, The British University in Egypt, El-Sherouk City, Cairo, 11837, Egypt.

Journal of Nanobiotechnology
|March 6, 2022
PubMed

Insights

Lipid-based nanoparticles show promise for improving hepatocellular carcinoma treatment outcomes. This review explores various nanoparticle types and tumor targeting strategies to enhance drug delivery for liver cancer.

Area of Science:

  • Oncology
  • Nanotechnology
  • Drug Delivery

Background:

  • Hepatocellular carcinoma (HCC) is a leading cause of cancer mortality globally.
  • Conventional treatments for HCC often yield suboptimal clinical results.
  • There is a critical need for advanced therapeutic strategies to improve HCC management.

Purpose of the Study:

  • To review the application of lipid-based nanoparticles (LNPs) in hepatocellular carcinoma treatment.
  • To discuss various LNP formulations and their potential benefits.
  • To explore strategies for enhancing tumor uptake and specificity of LNP drug delivery.

Main Methods:

  • Literature review of studies on lipid-based nanoparticles for liver cancer.
  • Analysis of different LNP types: liposomes, solid lipid nanoparticles, nanostructured lipid carriers, etc.
  • Examination of tumor targeting techniques: passive, active, and stimuli-responsive approaches.

Main Results:

  • LNPs offer a promising platform for improving drug delivery in HCC.
  • Various LNP formulations demonstrate potential for enhanced therapeutic efficacy.
  • Targeting strategies can significantly improve nanoparticle accumulation within tumors.

Conclusions:

  • Lipid-based nanoparticles represent a significant advancement in the treatment of hepatocellular carcinoma.
  • Optimizing LNP design and employing targeted delivery systems are crucial for maximizing treatment effectiveness.
  • Further research into LNP-based therapies holds great potential for managing liver cancer.
Keywords:
Lipidic nanoparticlesLiposomesNanostructured lipid carriersSolid lipid nanoparticlesTargeting approaches

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