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Related Experiment Videos

Rociverine for nocturia in the elderly: medium-term controlled clinical trial.

L Daccò, M Barbagallo, A Carbognati

    Clinical Therapeutics
    |January 1, 1986
    PubMed
    Summary

    Rociverine significantly reduced nighttime urination more effectively than flavoxate in patients with nocturia. Both drugs were well-tolerated, offering potential treatment options for reducing nocturnal voidings.

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    Area of Science:

    • Urology
    • Pharmacology

    Background:

    • Nocturia, or nighttime urination, affects many adults aged 51-79.
    • Causes include bladder instability, postural edema resorption, and age-related changes.
    • Current treatments aim to reduce or eliminate nocturnal voidings.

    Purpose of the Study:

    • To compare the efficacy of rociverine and flavoxate in treating nocturia.
    • To assess the reduction in nocturnal voidings with these two medications.

    Main Methods:

    • A randomized trial involving 40 patients (51-79 years old) with nocturia.
    • Patients received either 20 mg rociverine or 200 mg flavoxate at 8 PM.
    • Key metrics included number of night voidings, urine volume, and timing, assessed over 28 days.

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    Main Results:

    • Both rociverine and flavoxate were well-tolerated based on laboratory tests.
    • Rociverine demonstrated a statistically significant greater reduction in the number of night voidings compared to flavoxate (P < 0.05).

    Conclusions:

    • Rociverine is more effective than flavoxate in reducing nocturnal voidings in patients with nocturia.
    • Both drugs show good tolerability, suggesting potential therapeutic benefits for nocturia management.