Molecular mechanisms regulating the spatial configuration of neurites

Precise neural networks, composed of axons and dendrites, are the structural basis for information processing in the brain. Therefore, the correct formation of neurites is critical for accurate neural function. In particular, the three-dimensional structures of dendrites vary greatly among neuron types, and the unique shape of each dendrite is tightly linked to specific synaptic connections with innervating axons and is correlated with its information processing. Although many systems are involved in neurite formation, the developmental mechanisms that control the orientation, size, and arborization pattern of neurites definitively defines their three-dimensional structure in tissues. In this review, we summarize these regulatory mechanisms that establish proper spatial configurations of neurites, especially dendrites, in invertebrates and vertebrates.