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Inhaled Medications

Inhaled Medications

Inhaled medications are crucial for managing chronic obstructive pulmonary disease (COPD) and asthma. They are essential for effective treatment and control, ensuring optimal respiratory health and well-being. Inhaled medication delivers drugs directly to the lungs, providing a rapid onset of action and reducing systemic side effects compared to oral or injectable medications. Three primary types of inhalation devices are used to administer these medications: nebulizers, metered-dose inhalers...

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Related Experiment Video

Updated: Oct 1, 2025

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System

Published on: April 6, 2017

Particle engineering in dry powders for inhalation.

Regina Scherließ¹, Simon Bock¹, Nicholas Bungert¹

¹Department of Pharmaceutics and Biopharmaceutics, Kiel University, Grasweg 9a, 24118 Kiel, KiNSIS Priority Research Area, Kiel University.

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences

|March 6, 2022

Summary

Particle engineering enhances dry powder inhalation (DPI) formulations for improved respiratory drug delivery. This review details particle engineering techniques for carrier-based and carrier-free systems, exploring future additive manufacturing applications.

Keywords:

Pulmonary drug delivery additive manufacturing carrier engineering microparticles nanocrystals nanoparticles

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Last Updated: Oct 1, 2025

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System

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Published on: April 6, 2017

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Published on: August 18, 2023

Area of Science:

Pharmaceutical Sciences
Biotechnology
Materials Science

Background:

Inhalation drug delivery offers advantages for respiratory and systemic diseases.
Dry powder inhalation (DPI) is a promising but challenging drug delivery method.
Current DPI formulations face limitations in drug delivery efficiency and targeting.

Purpose of the Study:

To review particle engineering as a formulation technique for pulmonary drug delivery.
To explore methods for optimizing existing DPI strategies and developing new ones.
To discuss carrier-based and carrier-free technologies for inhalation.

Main Methods:

Comprehensive review of particle engineering techniques for DPI.
Analysis of carrier attributes and modification methods.
Examination of nanocrystal, nanoparticle, and carrier-free technologies.
Discussion of additive manufacturing for future carrier engineering.

Main Results:

Particle engineering offers solutions to improve DPI formulation efficacy and safety.
Various techniques exist for modifying carrier attributes or manufacturing desired carriers.
Nanocrystal, nanoparticle, and carrier-free technologies show potential for advanced applications.
Additive manufacturing presents future opportunities in carrier engineering.

Conclusions:

Particle engineering is crucial for advancing pulmonary drug delivery via DPI.
Diverse particle engineering approaches can overcome current formulation challenges.
Future innovations, including additive manufacturing, will further enhance inhalation therapies.