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Updated: Oct 1, 2025

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition
Published on: March 11, 2021
Realization and dissemination of activity standards for medically important alpha-emitting radionuclides
Denis E Bergeron1, Karsten Kossert2, Sean M Collins3
1Physical Measurement Laboratory, National Institute of Standards and Technology, Gaithersburg, MD, 20899-8462, USA.
Abstract:
Interest in targeted cancer therapy with alpha-emitting radionuclides is growing. To evaluate emerging radiotherapeutic agents requires precise activity measurements for consistent dose-response relationships and patient-specific dosimetry. National metrology institutes around the world have reported on the development and comparison of activity standards for medically important alpha emitters. This review describes the relevant methods and models underpinning these standards, the generation of new nuclear decay data, and the impacts on preclinical and clinical activity assays using radionuclide calibrators and γ-ray spectrometry.
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