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Nanomaterial-Based Biosensors using Field-Effect Transistors: A Review
T Manimekala1,2, R Sivasubramanian2, Gnanaprakash Dharmalingam1
1Plasmonic Nanomaterials Laboratory, PSG Institute of Advanced Studies, Peelamedu, Coimbatore, Tamilnadu 641004 India.
Journal of Electronic Materials
|March 7, 2022
Summary
Field-effect transistor biosensors (Bio-FETs) offer high sensitivity for detecting various biomarkers. Nanomaterial-based Bio-FETs show promise for portable diagnostics and advanced sensing applications.
Area of Science:
- Biosensors and electronic devices
- Nanomaterials in sensing technology
Background:
- Field-effect transistor biosensors (Bio-FETs) are gaining attention for their sensitivity, selectivity, and integration into portable electronics.
- The performance of Bio-FETs depends critically on the bio-recognition layer and transducer for stability and sensitivity.
Purpose of the Study:
- To review the fundamental concepts, working principles, and recent advancements in nanomaterial-based Bio-FETs.
- To highlight the application of these biosensors in detecting various biomarkers including neurotransmitters, glucose, nucleic acids, proteins, viruses, and cancer markers.
Main Methods:
- Review of current literature on nanomaterial-based Field-effect transistor biosensors.
- Focus on the application of nanomaterials in enhancing Bio-FET performance for specific analyte detection.
Main Results:
- Nanomaterials significantly improve the sensitivity, stability, and selectivity of Bio-FETs.
- Successful detection of diverse analytes such as neurotransmitters, glucose, nucleic acids, proteins, viruses, and cancer biomarkers has been demonstrated.
Conclusions:
- Nanomaterial-based Bio-FETs are highly promising for sensitive and selective biosensing.
- Further research and development are needed to overcome current challenges and realize the full potential of nano Bio-FETs in various applications.
