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Updated: Oct 1, 2025

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Decrease in Plasma miR-27a and miR-221 After Concussion in Australian Football Players.

Sandy R Shultz1,2, Caroline J Taylor3, Riemke Aggio-Bruce4,5

  • 1Department of Neuroscience, Monash University, Melbourne, VIC, Australia.

Biomarker Insights
|March 7, 2022
PubMed
Summary
This summary is machine-generated.

Specific microRNAs (miRNAs) show altered levels after sports-related concussion (SRC). Decreased levels of miR-27a-3p and miR-221-3p correlate with symptom severity, offering potential biomarkers for concussion management.

Keywords:
Traumatic brain injurybiomarkerinflammationmild traumatic brain injurypathophysiologyvascular injury

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Area of Science:

  • Neuroscience
  • Biochemistry
  • Sports Medicine

Background:

  • Sports-related concussion (SRC) lacks reliable clinical decision-making methods.
  • MicroRNAs (miRNAs) are implicated in SRC biological processes.
  • Circulating miRNAs may serve as diagnostic and recovery biomarkers.

Purpose of the Study:

  • To investigate the temporal profile of circulating miRNA levels in athletes after SRC.
  • To identify potential miRNA biomarkers for SRC severity and recovery.

Main Methods:

  • Prospective study of Australian rules football players.
  • Blood samples collected pre-season and at 2, 6, and 13 days post-SRC.
  • miRNA expression analyzed using Open Array and qRT-PCR.

Main Results:

  • 18 candidate miRNAs identified in discovery analysis.
  • Plasma miR-221-3p levels decreased at 6 and 13 days post-SRC.
  • Plasma miR-27a-3p levels decreased at 6 days post-SRC.
  • miR-27a and miR-221-3p levels inversely correlated with SRC symptom severity.

Conclusions:

  • Circulating miR-27a-3p and miR-221-3p levels are decreased in the sub-acute stages after SRC.
  • These miRNAs correlate with SRC symptom severity.
  • Identified potential miRNA biomarkers for SRC clinical management.