Related Experiment Video
Updated: Oct 1, 2025
08:55
Online Transcranial Magnetic Stimulation Protocol for Measuring Cortical Physiology Associated with Response Inhibition
Published on: February 8, 2018
9.3K
Cortical Inhibition State-Dependent iTBS Induced Neural Plasticity
Xiaoying Diao1,2, Qian Lu1, Lei Qiao3
1Department of Rehabilitation Medicine, The Affiliated Jiangsu Shengze Hospital of Nanjing Medical University, Suzhou, China.
Frontiers in Neuroscience
|March 7, 2022
Summary
Lower baseline GABAergic activity, measured by SICI, predicts greater long-term potentiation-like plasticity after intermittent theta burst stimulation (iTBS). This finding helps personalize iTBS protocols for enhanced cortical excitability effects.
Area of Science:
- Neuroscience
- Neurophysiology
- Brain Stimulation
Background:
- Intermittent theta burst stimulation (iTBS) induces long-term potentiation (LTP)-like plasticity, but its effects vary individually.
- Local gamma-aminobutyric acid (GABA) levels and N-methyl-D-aspartate (NMDA) receptor activity are crucial for LTP-like plasticity.
Purpose of the Study:
- To investigate the correlation between pre-stimulation GABAergic or NMDA receptor activity and the cortical excitability changes induced by iTBS.
- To determine if baseline neurotransmitter activity predicts individual responses to iTBS.
Main Methods:
- Fifteen healthy volunteers underwent assessments of short-interval intracortical inhibition (SICI), long-interval intracortical inhibition (LICI), and intracortical facilitation (ICF) before iTBS.
- These measures indexed GABAA, GABAB, and glutamate receptor activity, respectively.
- Cortical excitability after iTBS was assessed by changes in motor-evoked potential (MEP) amplitude.
Main Results:
- A significant negative correlation was found between baseline SICI (GABAA receptor activity) and iTBS-induced LTP-like plasticity.
- SICI levels before stimulation predicted cortical excitability changes at 5, 10, and 15 minutes post-iTBS.
Conclusions:
- Baseline GABAA receptor-mediated activity, indexed by SICI, negatively correlates with iTBS-induced cortical excitability.
- SICI serves as a potential predictor of iTBS-induced LTP-like plasticity for up to 15 minutes post-stimulation.
Related Concept Videos
01:35Long-term Potentiation
56.0K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
56.0K
01:03Long-term Depression
2.7K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
Calcium Ion Concentration Mechanism
If over...
2.7K
01:01Neuroplasticity
889
Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
889