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Updated: Oct 1, 2025

Behavioral And Physiological Analysis In A Zebrafish Model Of Epilepsy
Published on: October 19, 2021
A Review of Targeted Therapies for Monogenic Epilepsy Syndromes
Vincent Zimmern1, Berge Minassian1, Christian Korff2
1Division of Child Neurology, University of Texas Southwestern, Dallas, TX, United States.
Abstract:
Genetic sequencing technologies have led to an increase in the identification and characterization of monogenic epilepsy syndromes. This increase has, in turn, generated strong interest in developing "precision therapies" based on the unique molecular genetics of a given monogenic epilepsy syndrome. These therapies include diets, vitamins, cell-signaling regulators, ion channel modulators, repurposed medications, molecular chaperones, and gene therapies. In this review, we evaluate these therapies from the perspective of their clinical validity and discuss the future of these therapies for individual syndromes.
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