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A Bidirectional Relationship Between Hyperuricemia and Metabolic Dysfunction-Associated Fatty Liver Disease
Chengzhang Yang1,2, Qianjin He3,4, Ze Chen2,5
1Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China.
Frontiers in Endocrinology
|March 7, 2022
Summary
Hyperuricemia and metabolic dysfunction-associated fatty liver disease (MAFLD) share a bidirectional relationship in the Chinese population. This vicious cycle can lead to a worsening of metabolic health.
Area of Science:
- Metabolic diseases
- Hepatology
- Epidemiology
Background:
- Metabolic dysfunction-associated fatty liver disease (MAFLD) is a new term for nonalcoholic fatty liver disease (NAFLD).
- The association between hyperuricemia and MAFLD in Chinese populations is not well understood.
- The temporal relationship between hyperuricemia and MAFLD requires further investigation.
Purpose of the Study:
- To explore the association between hyperuricemia and MAFLD in a large Chinese cohort.
- To examine the temporal relationship between hyperuricemia and MAFLD using longitudinal data.
- To investigate the bidirectional nature of the association between hyperuricemia and MAFLD.
Main Methods:
- Retrospective cross-sectional study of 1,587,962 individuals (2009-2017).
- Longitudinal cohort study of 16,112 individuals.
- Logistic and Cox regression models, and cross-lagged analysis were used to assess associations and temporal relationships.
Main Results:
- Hyperuricemia was positively associated with MAFLD in the cross-sectional analysis.
- Baseline hyperuricemia predicted new-onset MAFLD (HR: 1.765).
- Baseline MAFLD predicted subsequent hyperuricemia (HR: 1.245), indicating a bidirectional relationship.
Conclusions:
- Hyperuricemia and MAFLD are bidirectionally associated in the Chinese population.
- These conditions form a vicious cycle, potentially exacerbating metabolic dysfunction.
- Findings highlight the importance of managing hyperuricemia in MAFLD patients and vice versa.
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