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Identification of Resolvin D1 and Protectin D1 as Potential Therapeutic Agents for Treating Kidney Stones

Bohan Wang1, Jingchao Wei1, Qi Huangfu1

  • 1Department of Urology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310000, China.

Oxidative Medicine and Cellular Longevity
|March 7, 2022
PubMed

Insights

This study identifies key lipids, Resolvin D1 (RvD1) and Protectin D1 (PD1), that are decreased in kidney stone patients. Supplementation with RvD1 and PD1 shows therapeutic potential by reducing calcium oxalate deposition and kidney injury.

Area of Science:

  • Nephrology
  • Lipidomics
  • Biochemistry

Background:

  • Intrarenal calcium oxalate (CaOx) crystals cause significant renal tubular epithelial cell (TEC) injury.
  • Lipids play a role in various diseases and kidney stone risk.
  • Understanding lipid profiles in kidney stone patients is crucial for identifying therapeutic targets.

Purpose of the Study:

  • To explore potential therapeutic lipid components in kidney stones.
  • To identify serum lipid differences between kidney stone patients and healthy controls.
  • To evaluate the therapeutic effects of identified lipids on CaOx deposition and injury.

Main Methods:

  • Serum samples from 35 kidney stone patients and 35 controls were analyzed for lipid components.
  • A CaOx nephrocalcinosis mouse model was used to test therapeutic lipid effects.
  • Key oxidative stress markers (SOD2, NOX2, ROS) were measured in vivo.

Main Results:

  • Resolvin D1 (RvD1) and Protectin D1 (PD1) were significantly decreased in kidney stone patients.
  • RvD1 and PD1 administration inhibited CaOx deposition and reduced TEC injury in mice.
  • RvD1 and PD1 modulated oxidative stress markers, decreasing ROS levels.

Conclusions:

  • RvD1 and PD1 are potential therapeutic agents for kidney stones.
  • These lipids mitigate CaOx-induced renal injury by reducing oxidative stress.
  • This study offers a promising new perspective for kidney stone treatment strategies.

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