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Updated: Oct 1, 2025

Detection of Architectural Distortion in Prior Mammograms via Analysis of Oriented Patterns

Detection of Architectural Distortion in Prior Mammograms via Analysis of Oriented Patterns

Published on: August 30, 2013

Breast microcalcifications: Past, present and future (Review).

Angela F Logullo^1,2, Karla C K Prigenzi², Cristiane C B A Nimir²

¹Department of Pathology, Paulista School of Medicine, Federal University of São Paulo (UNIFESP), São Paulo 04023-062, Brazil.

Molecular and Clinical Oncology

|March 7, 2022

Summary

Mammary microcalcifications (MCs), calcium deposits on mammography, are key breast cancer markers. Different MC types, like calcium oxalate or hydroxyapatite, indicate benign or malignant conditions, aiding diagnosis.

Keywords:

breast cancer breast diagnosis mammogram microcalcifications radiological and pathological aspects

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Last Updated: Oct 1, 2025

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Area of Science:

Radiology
Pathology
Oncology

Background:

Mammary microcalcifications (MCs) are crucial mammographic markers, often linked to premalignant and malignant breast lesions.
MCs represent calcium deposits within breast tissue, requiring detailed radiological and pathological assessment.

Purpose of the Study:

To review mammary microcalcification types, their radiological and pathological features, and clinical significance.
To provide insights into MCs as potential active pathological mineralization processes.
To highlight the importance of radiological-pathological correlation in managing breast specimens.

Main Methods:

Literature review of mammary microcalcifications.
Analysis of radiological classifications (benign vs. suspicious).
Pathological examination of MC composition (calcium oxalate, hydroxyapatite, magnesium-associated hydroxyapatite).

Main Results:

MCs are classified based on composition: calcium oxalate (typically benign) and hydroxyapatite/magnesium-associated hydroxyapatite (primarily associated with malignancy).
Radiological assessment categorizes MCs as benign or suspicious.
MCs may indicate active pathological mineralization, not just passive degeneration or necrosis.

Conclusions:

Understanding MC types and their association with benign or malignant lesions is vital for accurate breast cancer diagnosis.
Fine-tuned radiological-pathological procedures are essential for practical breast specimen management.
Further research into MC molecular and structural development could improve breast lesion detection and treatment strategies.