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Management Strategies for Large Brain Metastases
Nehaw Sarmey1, Tehila Kaisman-Elbaz1, Alireza M Mohammadi1
1Department of Neurosurgery, Rose Ella Burkhardt Brain Tumor and Neuro-oncology Center, Cleveland Clinic, Cleveland, OH, United States.
Frontiers in Oncology
|March 7, 2022
Summary
Brain metastases are common, but no single treatment is best. Personalized strategies considering patient and tumor factors are key for managing intracranial neoplasms effectively.
Area of Science:
- Neuro-oncology
- Neurosurgery
- Radiation Oncology
Background:
- Brain metastases are the most frequent intracranial tumors, causing significant patient and healthcare burdens.
- Historically, whole brain radiation therapy was the primary treatment, but new strategies have emerged.
Purpose of the Study:
- To review recent literature on treatment strategies for brain metastases.
- To discuss the roles of surgery, whole brain radiation therapy, stereotactic radiosurgery, and combination therapies.
Main Methods:
- Literature review of recent studies on brain metastasis treatments.
- Analysis of surgical resection, whole brain radiation therapy, and stereotactic radiosurgery outcomes.
Main Results:
- Chemotherapeutic options for brain metastases are limited.
- Surgery, stereotactic radiosurgery, and combination therapies have advanced treatment paradigms.
- No single treatment is universally effective for all patients.
Conclusions:
- Treatment selection for brain metastases should be individualized.
- Patient and tumor characteristics are crucial for determining optimal therapeutic strategies.
- A multidisciplinary approach is essential for managing intracranial metastatic disease.
