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Disposable biosensors based on metal nanoparticles.

S Malathi1, I Pakrudheen2, S Narayana Kalkura1

  • 1Crystal Growth Centre, Anna University, Guindy, Chennai, 600025, India.

Sensors International
|March 7, 2022
PubMed
Summary
This summary is machine-generated.

Disposable biosensors utilizing metal nanoparticles offer rapid, low-cost detection of viruses like COVID-19. This review covers their application in enzymatic, non-enzymatic, immunosensors, and genosensors for point-of-care diagnostics.

Keywords:
COVID-19Disposable biosensorElectrochemical sensorEnzymatic biosensorImmunosensorMetal nanoparticles

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Area of Science:

  • Nanotechnology
  • Biomedical Engineering
  • Analytical Chemistry

Background:

  • The COVID-19 pandemic underscored the need for rapid, affordable diagnostic tools.
  • Disposable biosensors offer a promising solution for point-of-care detection.
  • Metal nanoparticles enhance biosensor performance and sensitivity.

Purpose of the Study:

  • To review the applications of metal nanoparticle-based disposable biosensors.
  • To discuss their use in enzymatic, non-enzymatic, immunosensors, and genosensors.
  • To highlight their relevance for point-of-care diagnostics, including COVID-19 detection.

Main Methods:

  • Review of existing literature on metal nanoparticle-based biosensors.
  • Categorization of biosensors based on detection principles (enzymatic, non-enzymatic, immunosensors, genosensors).
  • Analysis of performance characteristics such as sensitivity, specificity, and response time.

Main Results:

  • Metal nanoparticles significantly improve the sensitivity and response time of disposable biosensors.
  • These biosensors are effective for detecting various analytes, including glucose, H2O2, and pathogens.
  • Specific applications in immunosensors and genosensors demonstrate potential for disease diagnostics.

Conclusions:

  • Disposable metal nanoparticle-based biosensors are crucial for rapid and cost-effective point-of-care diagnostics.
  • Their versatility makes them suitable for detecting a wide range of biomarkers.
  • Further development can enhance their role in managing infectious diseases like COVID-19.