Related Experiment Video
Updated: Oct 1, 2025

Hemodynamic Precision in the Neonatal Intensive Care Unit using Targeted Neonatal Echocardiography
Published on: January 27, 2023
Different approaches for patent ductus arteriosus in premature infants using acetaminophen
Aimann Surak1, Amish Jain2, Abbas Hyderi3
1Northern Alberta Neonatal Program Royal Alexandra Hospital Site NICU, DTC 5027, Stollery Children Hospital, University of Alberta, 10240 Kingsway NW, Edmonton, AB, T5H 3V9, Canada. aimannsurak@gmail.com.
Background:
Acetaminophen use for pharmacological treatment of hemodynamically significant patent ductus arteriosus (hsPDA) in preterm infants is becoming more popular with emerging evidence that it is effective as well as safe alternative for other agents used to close hsPDA.
Data Sources:
We performed a narrative review of literature about pharmacological treatment of PDA using acetaminophen.
Results:
Acetaminophen was used as a prophylaxis, symptomatic, targeted, and a rescue approach.
Conclusions:
It appears that acetaminophen could be used in different approaches to close the hsPDA. Long-term outcomes of acetaminophen exposure early in life still lack certainty.
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