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Updated: Oct 1, 2025

Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson's Disease
Published on: January 7, 2014
T Lymphocytes in Parkinson's Disease
Elena Contaldi1,2, Luca Magistrelli1,3, Cristoforo Comi4
1Department of Translational Medicine, Movement Disorders Centre, University Hospital 'Maggiore della Caritá', University of Piemonte Orientale, Novara, Italy.
Abstract:
T cells are key mediators of both humoral and cellular adaptive immune responses, and their role in Parkinson's disease (PD) is being increasingly recognized. Several lines of evidence have highlighted how T cells are involved in both the central nervous system and the periphery, leading to a profound imbalance in the immune network in PD patients. This review discusses the involvement of T cells in both preclinical and clinical studies, their importance as feasible biomarkers of motor and non-motor progression of the disease, and recent therapeutic strategies addressing the modulation of T cell response.
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