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Publication rate and research topics of studies in pediatric kidney transplantation

Christian Patry1, Stefanie Cordts1, Lukas Baumann2

  • 1Department of Pediatrics I, University Children's Hospital Heidelberg, Heidelberg, Germany.

Pediatric Transplantation
|March 7, 2022
PubMed

Insights

Nearly half of pediatric kidney transplant studies remain unpublished, potentially biasing clinical decisions. Industry-funded research shows higher publication rates, with faster publication times in recent years.

Area of Science:

  • Pediatric Nephrology
  • Transplantation Research
  • Clinical Trial Publication

Background:

  • High-quality medical care for pediatric kidney transplant recipients relies on robust evidence from clinical trials.
  • Understanding publication trends is crucial for assessing the evidence base in this field.

Purpose of the Study:

  • To analyze the publication rate, time to publication, and influencing factors for studies in pediatric kidney transplantation.
  • To identify research areas with low publication rates and potential publication bias.

Main Methods:

  • A comprehensive review of pediatric kidney transplantation studies registered on ClinicalTrials.gov from 1999 to 2020.
  • Analysis of publication status, time to publication, research topics, and funding sources.

Main Results:

  • Out of 136 studies (36,255 participants), only 58.8% were published, leaving data from 14,350 participants unpublished.
  • Median time to publication was 25 months, with faster publication in recent years.
  • Industry-funded studies had a significantly higher 5-year publication rate (p=0.019).

Conclusions:

  • A significant proportion of pediatric kidney transplantation research remains unpublished, raising concerns about publication bias.
  • This lack of publication may negatively impact clinical decision-making and patient care.
  • Industry funding appears to be associated with improved study publication rates.
Abstract

Keywords:
pediatric kidney transplantationpublication biaspublication ratesponsoringtime to publication

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