VITT with inactivated SARS-CoV-2 vaccine - index case

Area of Science:

• Immunology
• Hematology
• Vaccinology

Background:

• COVID-19 vaccines have been crucial in global pandemic control.
• Rare adverse events following vaccination require thorough investigation and reporting.

Observation:

• A 73-year-old male developed pulmonary embolism and thrombocytopenia.
• These symptoms appeared two weeks post-inactivated COVID-19 vaccination.

Findings:

• The patient was diagnosed with vaccine-induced immune thrombotic thrombocytopenia (VITT).
• Successful treatment was achieved using nonheparin anticoagulation.
• Complete resolution of thrombocytopenia and pulmonary embolism was observed.

Implications:

• This case highlights a potential rare complication of inactivated COVID-19 vaccines.
• Nonheparin anticoagulation is an effective treatment strategy for VITT.
• Further research into VITT mechanisms and prevention is warranted.