Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Oligosaccharide Assembly01:24

Oligosaccharide Assembly

3.0K
Protein glycosylation starts in the ER lumen and continues in the Golgi apparatus. Glycosyltransferases catalyze the addition of sugar molecules or glycosylation of proteins. Usually, these enzymes add sugars to the hydroxyl groups of selected serine or threonine residues to form O-linked glycans or the amino groups of asparagine residues to form N-linked glycans. Different positions on the same polypeptide chain can contain differently linked glycans.
Multiple sugar molecules that may or may...
3.0K
Formation of Lipopolysaccharides01:19

Formation of Lipopolysaccharides

147
Lipopolysaccharides (LPS) are crucial components of the outer membrane of Gram-negative bacteria, serving both structural and functional roles. It contributes to membrane stability and protects bacteria from host immune responses. LPS is composed of three major regions—lipid A, a core oligosaccharide, and an O antigen. The biosynthesis and assembly of LPS involve a highly coordinated set of enzymatic reactions and transport mechanisms. Additionally, LPS is recognized as an endotoxin,...
147

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mechanisms underlying the freezing and melting behavior of water confined in silica nanopores as a function of pore size and pore filling.

Physical chemistry chemical physics : PCCP·2025
Same author

Markovian Timescales of Intramolecular Disulfide Pairing in Cyclotides.

Proteins·2025
Same author

Effect of Anomers and Glycosidic Linkages on the Thermodynamics of Mechanically Stretched Oligosaccharides.

Journal of chemical information and modeling·2025
Same author

Directing the adsorption and assembly of laponite nano-discs at oil-water interfaces.

Nanoscale advances·2025
Same author

Elucidating molecular scale interactions underlying the freezing behavior of salt solutions in silica nanopores.

Physical chemistry chemical physics : PCCP·2025
Same author

The effect of H<sub>2</sub> occupancy modes in small and large cages of H<sub>2</sub>-tetrahydrofuran hydrates on the hydrates' stability and H<sub>2</sub> storage capacity.

Physical chemistry chemical physics : PCCP·2025
Same journal

Anti-mycobacterial activity of phytocompounds from <i>Ricinus communis</i> L. - an integrated <i>in-vitro</i> and <i>in-silico</i> approach.

Journal of biomolecular structure & dynamics·2026
Same journal

Binding studies of the X-ray characterized [SnMe<sub>2</sub>Cl<sub>2</sub>(Me<sub>2</sub>phen)] complex with human serum albumin: experimental and molecular docking approaches.

Journal of biomolecular structure & dynamics·2026
Same journal

Computational design and experimental validation of peptide inhibitors to disrupt urease enzyme maturation in pathogenic bacteria <i>Proteus mirabilis</i>.

Journal of biomolecular structure & dynamics·2026
Same journal

Wavelet-domain multiway spectral separation of free drug, DNA, and drug-DNA complex profiles for quantitative binding analysis based on fractional occupancy (<i>θ</i>).

Journal of biomolecular structure & dynamics·2026
Same journal

Gene expression and microsecond scale conformational dynamics suggest potential regulatory mechanisms for the expanded subtilase family of <i>T. rubrum</i>.

Journal of biomolecular structure & dynamics·2026
Same journal

Deciphering the Role of Sugar Osmolytes in Free and Nano forms to Mitigate Protein Aggregation: Insights from Biophysical and Microscopic Studies.

Journal of biomolecular structure & dynamics·2026
See all related articles

Related Experiment Video

Updated: Oct 1, 2025

High-throughput Synthesis of Carbohydrates and Functionalization of Polyanhydride Nanoparticles
14:37

High-throughput Synthesis of Carbohydrates and Functionalization of Polyanhydride Nanoparticles

Published on: July 6, 2012

11.6K

Monosaccharide induced temporal delay in cholesterol self-aggregation.

Rituparna Hazra1, Durba Roy1

  • 1Department of Chemistry, Birla Institute of Technology and Science-Pilani, Hyderabad Campus, Hyderabad, Telangana, India.

Journal of Biomolecular Structure & Dynamics
|March 7, 2022
PubMed
Summary
This summary is machine-generated.

Beta-D-glucose (BGLC), a component of beta-glucans, hinders cholesterol (CHL) self-assembly. This molecular interaction disrupts CHL aggregation, potentially impacting health conditions linked to high cholesterol.

Keywords:
Glucoseaggregationcholesterolinhibitionmolecular dynamicsself-assembly

More Related Videos

Single-Molecule Diffusion and Assembly on Polymer-Crowded Lipid Membranes
10:43

Single-Molecule Diffusion and Assembly on Polymer-Crowded Lipid Membranes

Published on: July 19, 2022

2.5K
Measuring the Time-Evolution of Nanoscale Materials with Stopped-Flow and Small-Angle Neutron Scattering
07:53

Measuring the Time-Evolution of Nanoscale Materials with Stopped-Flow and Small-Angle Neutron Scattering

Published on: August 6, 2021

2.3K

Related Experiment Videos

Last Updated: Oct 1, 2025

High-throughput Synthesis of Carbohydrates and Functionalization of Polyanhydride Nanoparticles
14:37

High-throughput Synthesis of Carbohydrates and Functionalization of Polyanhydride Nanoparticles

Published on: July 6, 2012

11.6K
Single-Molecule Diffusion and Assembly on Polymer-Crowded Lipid Membranes
10:43

Single-Molecule Diffusion and Assembly on Polymer-Crowded Lipid Membranes

Published on: July 19, 2022

2.5K
Measuring the Time-Evolution of Nanoscale Materials with Stopped-Flow and Small-Angle Neutron Scattering
07:53

Measuring the Time-Evolution of Nanoscale Materials with Stopped-Flow and Small-Angle Neutron Scattering

Published on: August 6, 2021

2.3K

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Computational Chemistry

Background:

  • Cholesterol (CHL) self-assembly is linked to adverse health outcomes like arterial plaques and gallstones.
  • Dietary carbohydrates, such as beta-glucans, can reduce serum CHL levels.
  • The precise mechanism by which these carbohydrates interfere with CHL aggregation is not fully understood.

Purpose of the Study:

  • To investigate how beta-D-glucose (BGLC), the monomeric unit of beta-glucans, affects cholesterol (CHL) aggregation at a molecular level.
  • To elucidate the dynamics of CHL self-assembly in the presence of BGLC using computational simulations.

Main Methods:

  • Molecular dynamics simulations were employed to model the interactions between CHL and BGLC.
  • Analysis included estimation of translational entropy, coordination numbers, and collective variables to assess CHL diffusion and packing.
  • Time evolution of CHL aggregation patterns was observed in systems with and without BGLC.

Main Results:

  • BGLC significantly slows down the diffusion of CHL molecules.
  • The presence of BGLC disrupts the formation of stable, hydrophobic CHL assemblies.
  • CHL molecules form transient, smaller clusters in the presence of BGLC, unlike the robust assemblies in its absence.

Conclusions:

  • Beta-D-glucose (BGLC) interferes with cholesterol (CHL) self-assembly by retarding molecular motion and disrupting hydrophobic interactions.
  • The findings suggest a potential molecular mechanism for how beta-glucans may contribute to lowering serum CHL levels.
  • Understanding these interactions could inform strategies for managing cholesterol-related health issues.