Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Stroke: Introduction and Types

Stroke: Introduction and Types

A stroke is an acute neurological event caused by the sudden disruption of cerebral blood flow, leading to rapid loss of neuronal function. Neurons depend on continuous oxygen and glucose supply, so even brief interruptions can cause irreversible injury within minutes. Strokes are classified into ischemic and hemorrhagic types.Ischemic StrokeIschemic strokes are most common and occur due to arterial occlusion, depriving brain tissue of oxygen and nutrients. This leads to energy failure, ionic...

Ischemic Stroke ll: Pathophysiology

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...

Hemorrhagic Stroke l: Introduction

Hemorrhagic Stroke l: Introduction

A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...

Hemorrhagic Stroke ll: Pathophysiology

Hemorrhagic Stroke ll: Pathophysiology

A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Chorea as a Non-Thrombotic Manifestation in an Adolescent with Systemic Lupus Erythematosus, Antiphospholipid Syndrome and Heterozygous Prothrombin G20210A Gene Mutation: A Case Report.

Case reports in neurology·2026

Same author

Role of Perfusion Parameters on Outcomes and Safety of Endovascular Therapy in Posterior Cerebral Artery Stroke.

Stroke·2026

Same author

Diagnostic accuracy and safety of Diaskintest<sup>®</sup> compared with the tuberculin skin test for detecting tuberculosis infection in BCG-vaccinated Brazilian adults.

Frontiers in medicine·2026

Same author

First-Line Stent Retriever Versus Contact Aspiration or Combined Technique for Endovascular Therapy of Posterior Cerebral Artery Occlusion Stroke: The PLATO Study.

Stroke (Hoboken, N.J.)·2026

Same author

Neuroimaging in inborn errors of immunity: More than infections.

Neuroradiology·2026

Same author

Ependymal enhancement on MRI: imaging patterns and diagnostic algorithms - a pictorial essay.

Neuroradiology·2025

Search research articles

Related Experiment Video

Updated: Jun 24, 2026

A Swine Model of Neonatal Asphyxia

A Swine Model of Neonatal Asphyxia

Published on: October 11, 2011

Subpial Hemorrhage : A Distinctive Neonatal Stroke Pattern.

Catarina Pinto¹, Bruno Cunha², Mafalda Mendes Pinto³

¹Neuroradiology Department, Centro Hospitalar Universitário do Porto, Largo Prof. Abel Salazar, 4099-001, Porto, Portugal. cat.mendes.pinto@gmail.com.

Clinical Neuroradiology

|March 7, 2022

Summary

This summary is machine-generated.

Neonatal subpial hemorrhage, a rare stroke, shows a distinct MR pattern with venous infarction. This study in 10 neonates suggests a link to cerebellar microbleeds, aiding understanding of this condition.

Keywords:

Bleeding MRI Neonate Perinatal stroke SWI

More Related Videos

Transient Middle Cerebral Artery Occlusion Model of Neonatal Stroke in P10 Rats

Transient Middle Cerebral Artery Occlusion Model of Neonatal Stroke in P10 Rats

Published on: April 21, 2017

Modeling Neonatal Intraventricular Hemorrhage Through Intraventricular Injection of Hemoglobin

Modeling Neonatal Intraventricular Hemorrhage Through Intraventricular Injection of Hemoglobin

Published on: August 25, 2022

Related Experiment Videos

Last Updated: Jun 24, 2026

A Swine Model of Neonatal Asphyxia

A Swine Model of Neonatal Asphyxia

Published on: October 11, 2011

Transient Middle Cerebral Artery Occlusion Model of Neonatal Stroke in P10 Rats

Transient Middle Cerebral Artery Occlusion Model of Neonatal Stroke in P10 Rats

Published on: April 21, 2017

Modeling Neonatal Intraventricular Hemorrhage Through Intraventricular Injection of Hemoglobin

Modeling Neonatal Intraventricular Hemorrhage Through Intraventricular Injection of Hemoglobin

Published on: August 25, 2022

Area of Science:

Neonatal neurology
Pediatric neuroimaging
Stroke research

Background:

Subpial hemorrhage is a rare and poorly understood type of neonatal stroke.
Characterizing these hemorrhages is crucial for improving diagnosis and management.

Purpose of the Study:

To characterize a cohort of term and preterm neonates with subpial hemorrhages.
To enhance the understanding of the pathophysiology and clinical presentation of neonatal subpial hemorrhage.

Main Methods:

Retrospective review of clinical records and magnetic resonance (MR) imaging.
Analysis of data from neonates with subpial hemorrhage treated between 2010 and 2020.

Main Results:

10 neonates analyzed; 40% were term. Temporal lobe was the most common site (70%).
All patients had underlying brain infarction; 90% showed a yin-yang pattern on MR imaging.
Cerebellar microbleeds were observed in 60%, with no association between early prematurity and worse outcomes.

Conclusions:

Neonatal subpial hemorrhage presents a distinct MR pattern, often with underlying venous infarction.
A potential association between subpial hemorrhage and cerebellar microbleeds is suggested, requiring further investigation.
This study contributes to a better understanding of neonatal subpial hemorrhage in both term and preterm infants.