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Updated: Oct 1, 2025
09:19
Single Myofiber Culture Assay for the Assessment of Adult Muscle Stem Cell Functionality Ex Vivo
Published on: February 15, 2021
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Enhancing health span: muscle stem cells and hormesis
Edward J Calabrese1, Vittorio Calabrese2
1Department of Environmental Health Sciences, School of Public Health and Health Sciences, University of Massachusetts, Morrill I, N344, Amherst, MA, 01003, USA. edwardc@schoolph.umass.edu.
Biogerontology
|March 7, 2022
Summary
This study explores hormetic dose responses in muscle stem cells to combat sarcopenia, the age-related loss of muscle mass. Findings suggest hormesis can enhance cell function and resilience, offering strategies for preventing age-related muscle decline.
Area of Science:
- Gerontology
- Cell Biology
- Biomedical Science
Background:
- Sarcopenia, the age-related loss of muscle mass and function, poses a significant public health challenge.
- Current research focuses on interventions to delay or minimize sarcopenia's onset and severity.
Purpose of the Study:
- To identify and assess hormetic dose responses in animal model muscle stem cells.
- To explore the potential of hormesis in preventing sarcopenia by enhancing cell proliferation, differentiation, and stress resilience.
Main Methods:
- Investigated hormetic dose responses in muscle stem cells across various agents.
- Assessed cell proliferation, differentiation, and resilience to inflammatory stresses.
Main Results:
- Hormetic dose responses were observed with diverse agents including resveratrol, dexamethasone, TNF-α, cadmium, and low-level laser.
- These responses influenced muscle stem cell proliferation, differentiation, and inflammatory stress resilience.
Conclusions:
- Hormetic frameworks show potential for therapeutic applications in slowing age-related muscle loss and functional decline.
- Understanding hormetic mechanisms in muscle stem cells is crucial for developing sarcopenia prevention strategies.
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