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Updated: Oct 1, 2025
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Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
Published on: April 12, 2019
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Mandibular osteosarcoma: diagnosis and treatment.
Andrea Ferri1, Bernardo Bianchi1, Silvano Ferrari2
1Maxillo-Facial Surgery Division, Head and Neck Department, University Hospital of Parma.
Summary
Management of mandibular osteosarcoma lacks a standard of care. Surgical resection is key, with chemotherapy emerging as a vital adjuvant or neoadjuvant treatment for this rare bone cancer.
Area of Science:
- Oncology
- Oral and Maxillofacial Surgery
- Pathology
Background:
- Mandibular osteosarcoma is a rare malignancy.
- Literature review encompassing recent and seminal publications.
Purpose of the Study:
- To review current literature on mandibular osteosarcoma management.
- Focus on diagnosis, histotype, and treatment strategies.
Main Methods:
- Comprehensive literature search of publications over the last 5 years.
- Inclusion of significant historical publications due to tumor rarity.
Main Results:
- No established standard of care for mandibular osteosarcoma.
- Surgical resection with clear margins remains the primary treatment.
- Chemotherapy is increasingly utilized in neoadjuvant and adjuvant settings.
Conclusions:
- Lack of extensive randomized trials hinders definition of standard care.
- Diagnosis and treatment protocols are derived from varied reports.
- An interdisciplinary approach is essential for personalized patient management based on tumor and patient factors.
