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Updated: Oct 1, 2025

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Published on: May 22, 2018
Small Oligomers of Aβ42 Protein in the Bulk Solution with AlphaFold2
Hubert Santuz1, Phuong H Nguyen1, Fabio Sterpone1
1CNRS, Université de Paris, UPR 9080, Laboratoire de Biochimie Théorique, Institut de Biologie Physico-Chimique, Fondation Edmond de Rothschild, 13 Rue Pierre et Marie Curie, 75005 Paris, France.
Abstract:
Aggregation of amyloid-β (Aβ42) protein is one hallmark of Alzheimer's disease, and the conformations of the smallest Aβ42 oligomers are largely unknown. Here, we explore the application of the deep learning AlphaFold2 method to the structure determination of Aβ42 monomers up to hexamers. The results shed light on the early Aβ42 aggregation steps in the bulk solution.
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