Nanoparticle-based strategies to target HIV-infected cells.

Area of Science:

• Nanomedicine
• Drug Delivery Systems
• Virology

Background:

• Antiretroviral drugs for human immunodeficiency virus (HIV) infections face challenges including poor bioavailability, adverse effects, and limited tissue penetration.
• Current treatment regimens often require long-term therapy and struggle with drug-drug interactions and access to viral reservoirs.

Purpose of the Study:

• To review nanocarrier-based strategies for improving antiretroviral drug delivery in HIV treatment.
• To highlight the advantages and disadvantages of various nanocarriers used in combating HIV infections.

Main Methods:

• Comprehensive literature review of nanocarrier applications in antiretroviral therapy.
• Analysis of studies focusing on nanocarrier-mediated delivery of drugs for HIV.

Main Results:

• Nanotechnology-based interventions show potential to overcome limitations of conventional antiretroviral drugs.
• Various nanocarriers have been explored for enhanced delivery, improved efficacy, and reduced side effects.

Conclusions:

• Nanocarriers represent a significant advancement in the therapeutic approach to HIV infection.
• Further research into nanocarrier systems is crucial for optimizing antiretroviral efficacy and patient outcomes.