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Campimetry and visual changes after RHZE treatment for tuberculosis
Brunella Maria Pavan Taffner1, Luiz Guilherme Ito da Cruz2, Flávio de Ávila Fowler2
1Departament of Ophthalmology, Federal University of São Paulo, UNIFESP, São Paulo, SP, Botucatu, 822, Vila Clementino, Brazil. brunellapavan@gmail.com.
Background:
Tuberculosis (TB) caused by Mycobacterium tuberculosis has a high prevalence in Brazil (Global tuberculosis report 2020. Geneva: World Health Organization; 2020). The ethambutol-induced optic neuropathy damage is partly reversible, making its early diagnosis essential to reduce permanent visual damage.
Purpose:
To observe alterations in the computerized campimetry, Ishihara test and visual acuity secondary to rifampicin, isoniazid, pyrimethamine, ethambutol (RHZE) treatment.
Methods:
Patients undergoing treatment with RHZE at the tuberculosis service of the Federal University of São Paulo were recruited from March 2019 to December 2020. The best-corrected visual acuity (VA) measurements, Ishihara test and visual fields were performed at baseline, monthly, until 2 weeks after treatment.
Results:
Twenty-five patients were included. The VA decreased significantly (P = 0.0129) post-treatment compared to month 1. The mean deviation (MD) did not decrease significantly (P > 0.05); the pattern standard deviation (PSD) decreased post-treatment compared to month 1 (P = 0.0371). Changes in the Ishihara test increased significantly (P < 0.0001) in the second month.
Conclusion:
The VA and PSD decreased significantly after RHZE treatment. Changes in the Ishihara test were observed in the second month.
Trial Registration:
The Research Ethics Committee of Federal University of São Paulo, Paulista School of Medicine approved the study in March 2019. CAAE 04297018.4.0000.5505.
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