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Campimetry and visual changes after RHZE treatment for tuberculosis
Brunella Maria Pavan Taffner1, Luiz Guilherme Ito da Cruz2, Flávio de Ávila Fowler2
1Departament of Ophthalmology, Federal University of São Paulo, UNIFESP, São Paulo, SP, Botucatu, 822, Vila Clementino, Brazil. brunellapavan@gmail.com.
International Journal of Retina and Vitreous
|March 8, 2022
Summary
Tuberculosis treatment with RHZE medication can cause vision problems. Early detection of ethambutol-induced optic neuropathy is crucial to prevent permanent vision loss in patients.
Area of Science:
- Ophthalmology
- Infectious Diseases
- Pharmacology
Background:
- Tuberculosis (TB) is highly prevalent in Brazil.
- Ethambutol-induced optic neuropathy can cause irreversible vision damage.
- Early diagnosis of optic neuropathy is vital for vision preservation.
Purpose of the Study:
- To assess visual acuity, Ishihara test results, and visual fields.
- To observe changes during and after standard tuberculosis treatment (RHZE).
Main Methods:
- 25 patients undergoing RHZE treatment were monitored.
- Visual acuity, Ishihara color vision testing, and visual fields were assessed monthly.
- Evaluations were conducted from baseline up to 2 weeks post-treatment.
Main Results:
- Visual acuity significantly decreased after RHZE treatment.
- Pattern standard deviation in visual fields showed a significant decrease.
- Significant changes in Ishihara test results were noted by the second month of treatment.
Conclusions:
- RHZE treatment led to significant decreases in visual acuity and pattern standard deviation.
- The Ishihara test indicated visual changes within two months of treatment.
- Monitoring visual function during TB treatment is essential.
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