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Updated: Oct 1, 2025
04:39
Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
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Thyroid autoimmunity and pregnancy in euthyroid women
Aglaia Kyrilli1, David Unuane2, Kris G Poppe3
1Department of Endocrinology, Hôpital Erasme (Université Libre de Bruxelles, ULB), Route de Lennik, 808, 1070, Brussels, Belgium.
Summary
Women with thyroid autoimmunity (TAI) face increased risks for pregnancy complications and subfertility. While TAI impacts maternal and fetal health, screening all pregnant women is not currently recommended due to unanswered questions.
Area of Science:
- Reproductive Endocrinology
- Immunology
- Obstetrics
Background:
- Thyroid autoimmunity (TAI), marked by elevated thyroid peroxidase antibodies (TPOAb), poses risks to pregnant women.
- TAI is linked to subfertility, higher TSH levels before pregnancy, and potential hypothyroidism during gestation.
Purpose of the Study:
- To review the significance of TAI during natal and perinatal periods.
- To explore the associations between TAI and pregnancy-related complications, including postpartum thyroiditis (PPT).
Main Methods:
- Literature review focusing on TAI and pregnancy outcomes.
- Analysis of existing studies on maternal and fetal complications in women with TAI.
Main Results:
- TAI is associated with increased maternal and fetal complications, even in euthyroid women, though causality is unclear.
- Nearly half of women with pre-pregnancy TAI develop postpartum thyroiditis (PPT); its link to postpartum depression is uncertain.
Conclusions:
- Further research is needed to elucidate the mechanisms linking TAI to pregnancy morbidities.
- Current evidence does not support routine screening for TAI in all pregnant women.
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