Related Experiment Video
Updated: Oct 1, 2025

Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection
Published on: June 8, 2020
The association between Fusobacterium nucleatum and cancer colorectal: A systematic review and meta-analysis
Paola Villar-Ortega1, Manuela Expósito-Ruiz2, Miguel Gutiérrez-Soto3
1Departamento de Microbiología, Universidad de Granada-Instituto de Investigación BioSanitaria-ibs-Granada, Granada, Spain.
Introduction:
The etiological factors of colorectal cancer (CRC) are not precisely known, although genetic and environmental factors have been implicated. A possible association with Fusobacterium nucleatum may provide opportunities for an early diagnosis.
Objective:
To review studies that address the association between F. nucleatum and CRC.
Methods:
The MEDLINE PubMed database was searched using the terms «colorectal cancer» and "Fusobacterium nucleatum", retrieving publications published up to January 1 2020. Stata software was used for a meta-analysis.
Results:
The systematic review included 57 articles. Meta-analysis results indicated a more frequent presence of F. nucleatum in CRC tumour tissue samples in comparison to control samples of healthy tissue, with an odds ratio of 4.558 (95% CI: 3.312-6.272), and in comparison, to control samples of colorectal adenomas, with an odds ratio of 3.244 (95 % CI: 2.359-4.462).
Conclusion:
There is a more frequent resence of F. nucleatum in the CRC. However, further studies are needed to verify this relationship.
Related Concept Videos
Serum Laboratory Studies, Stool Test, Breath Test
Cancer Prevention
Some...
NF-κB-dependent Signaling Pathway
NF-κB-dependent Signaling Mechanism
The...

