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Updated: Oct 1, 2025

Stereotactic Radiosurgery for Gynecologic Cancer
Published on: April 17, 2012
Radiation oncology management of stage III and IVA cervical carcinoma
Idalid Franco1, Akila N Viswanathan2
1Harvard Radiation Oncology Program, Harvard Medical School, Boston, Massachusetts, USA.
Abstract:
Worldwide, stage III-IVA carcinomas of the uterine cervix comprise a significant proportion of cases at presentation, and have a higher rate of recurrence and worse overall survival. This review will discuss the epidemiology, prevention strategies, clinical presentation, and treatment recommendations for stage III-IVA cervical cancer. The focus will be on the role of radiation therapy, concurrent chemoradiotherapy, and brachytherapy, including the potential benefits and anticipated toxicities. The unique challenges and considerations of fistula formation and approaches to management will be highlighted, and follow-up care and future directions discussed. As low and middle income countries bear the highest burden of advanced stage carcinoma of the uterine cervix, this review will address the unique needs of global communities.
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