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Myocarditis following COVID-19 mRNA vaccination

Kanak Parmar1, Poemlarp Mekraksakit1, Gaspar Del Rio-Pertuz1

  • 1Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas.

Proceedings (Baylor University. Medical Center)
|March 8, 2022
PubMed

Insights

Four patients experienced acute myocarditis-like illness after mRNA COVID-19 vaccination. This rare reaction warrants further investigation into vaccine safety and cardiac health.

Area of Science:

  • Cardiology
  • Immunology
  • Vaccinology

Background:

  • Messenger RNA (mRNA) vaccines are primary COVID-19 vaccines in the US.
  • Reported side effects are generally minor and temporary.

Observation:

  • A case series of four hospitalized patients in Lubbock, Texas, presented with acute myocarditis-like illness post-mRNA COVID-19 vaccination.
  • Three young men reported chest pain after their second mRNA-1273 vaccine dose.
  • A 53-year-old woman experienced left arm pain after the first mRNA-1273 dose, later diagnosed with heart failure.

Findings:

  • Endomyocardial biopsy in one patient revealed eosinophilic injury-mediated myocarditis.
  • The clinical presentation mimicked acute myocarditis in young males and included heart failure in an older female patient.

Implications:

  • This case series highlights a potential rare adverse event following mRNA COVID-19 vaccination.
  • Further research is needed to understand the mechanisms and incidence of vaccine-associated myocarditis.
  • Clinicians should be aware of these potential cardiac complications in vaccinated individuals.
Keywords:
COVID-19CorticosteroidsmRNA vaccinemyocarditis

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