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Elevated Thyroid Autoantibodies Aggravate Stroke Severity in Euthyroidism with Acute Ischemic Stroke.
Jingyi Li1, Shoulong Hu2, Fang Liu3
1The Department of Endocrinology, Beijing United Family Hospital, Beijing, China.
Disease Markers
|March 8, 2022
Summary
Thyroid autoantibodies worsen stroke severity in euthyroid patients with acute ischemic stroke (AIS). This suggests thyroid autoimmunity may increase risks of poor outcomes, independent of thyroid function.
Area of Science:
- Cardiology
- Endocrinology
- Neurology
Background:
- Immune reactions are linked to endothelial dysfunction and atherosclerosis.
- The association between thyroid dysfunction, autoantibodies, and atherosclerosis remains unclear.
Purpose of the Study:
- To investigate the impact of thyroid autoimmunity on functional outcomes in euthyroid patients with acute ischemic stroke (AIS).
Main Methods:
- Patients with AIS underwent thyroid function and autoantibody testing.
- Euthyroid AIS patients were categorized into positive and negative thyroid autoantibody groups.
- Demographics, risk factors, and functional outcomes were compared between groups.
Main Results:
- 11.8% of patients (50/422) had positive thyroid autoantibodies.
- The positive autoantibody group showed higher NIH Stroke Scale scores on admission and discharge.
- Mortality during hospitalization was significantly higher in the positive autoantibody group.
Conclusions:
- Thyroid autoantibodies exacerbate stroke severity in euthyroid patients with AIS.
- Thyroid autoimmunity may independently increase the risk of adverse outcomes through vascular damage, irrespective of thyroid function.
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