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Related Experiment Video

Updated: Oct 1, 2025

Interactive Molecular Model Assembly with 3D Printing

Interactive Molecular Model Assembly with 3D Printing

Published on: August 13, 2020

Digitizing Chemical Synthesis in 3D Printed Reactionware.

Andrius Bubliauskas¹, Daniel J Blair², Henry Powell-Davies¹

¹School of Chemistry, The University of Glasgow, Glasgow, G12 8QQ, UK.

Angewandte Chemie (International Ed. in English)

|March 8, 2022

Summary

This summary is machine-generated.

Digitizing organic synthesis requires standardized, modular hardware. This study presents a new approach combining process chemistry and 3D printed reactionware for reproducible chemical coding and synthesis.

Keywords:

3D Printing Chemical Education C−C Coupling Reactionware Unit Operations

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Area of Science:

Organic Chemistry
Chemical Engineering
Digital Chemistry

Background:

Standardizing chemistry digitization is crucial for linking experimental data and code.
Current methods lack standardization, hindering chemical code portability.
A universal approach using modular hardware and well-defined standards is needed.

Purpose of the Study:

To present a novel approach for digitizing organic synthesis.
To combine process chemistry principles with 3D printed reactionware.
To establish a standard for reproducible chemical coding.

Main Methods:

Developing a digitization process for organic synthesis.
Utilizing modular hardware and 3D printed reactionware.
Translating unit operations into digitized hardware and instructions.

Main Results:

Successfully digitized the synthesis of 3 MIDA boronate building blocks.
Demonstrated digitization for ester hydrolysis, Wittig olefination, and Suzuki-Miyaura coupling.
Outlined the process for synthesizing the drug sulfanilamide using the new method.

Conclusions:

The presented approach enables effective and reproducible organic synthesis digitization.
This method bridges process chemistry and digital tools for enhanced chemical coding.
The strategy facilitates the portability and standardization of chemical synthesis protocols.