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Is SARS-CoV-2 seroconversion a risk factor for severe and acute psychiatric symptoms in children?

Anaël Ayrolles1,2, Pierre Ellul1,2, Vincent Trebossen1,2

  • 1Child and Adolescent Psychiatry Department, Assistance Publique-Hôpitaux de Paris, Robert Debré Hospital, Paris, France.

Neuropsychopharmacology Reports
|March 8, 2022
PubMed

Insights

The COVID-19 pandemic saw more children with mental health issues. However, fewer children with severe psychiatric symptoms had COVID-19 antibodies, suggesting mitigation strategies, not the virus, worsened symptoms.

Area of Science:

  • Pediatric Psychiatry
  • Infectious Diseases
  • Epidemiology

Background:

  • The COVID-19 pandemic has been associated with increased mental health challenges in children.
  • Studies have raised questions about the direct impact of SARS-CoV-2 infection on pediatric psychiatric conditions.

Purpose of the Study:

  • To investigate the association between COVID-19 seroconversion and acute, severe psychiatric symptoms in hospitalized children.
  • To compare SARS-CoV-2 infection rates in children with severe psychiatric conditions versus a matched control group.

Main Methods:

  • A case-control study comparing 52 children hospitalized with acute, severe psychiatric symptoms to 52 sex- and age-matched controls.
  • Both groups were from the same low-income area and sampled during the same period.
  • COVID-19 seroconversion status was assessed for all participants.

Main Results:

  • A significantly lower proportion of children with psychiatric conditions showed COVID-19 seroconversion (9.61%) compared to the control group (34.61%).
  • Statistical analysis revealed a significant difference (χ² = 14.7, P = 1.24E-4) with an odds ratio of 0.20 (95% CI, 0.05-0.64).

Conclusions:

  • The findings suggest that SARS-CoV-2 infection may have a less direct impact on psychiatric symptom exacerbation in children than initially hypothesized.
  • The results point towards pandemic-related mitigation strategies potentially playing a more significant role in the observed increase in children's mental health issues.
Abstract

Keywords:
SARS-CoV-2childrenmental healthpandemicpsychiatric symptoms

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