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Related Experiment Video

Updated: Oct 1, 2025

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
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Drug repurposing for stroke intervention.

Debarati Ghosh1, Karan Sehgal1, Babasaheb Sodnar1

  • 1Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad, Gandhinagar, Gujarat, India.

Drug Discovery Today
|March 8, 2022
PubMed
Summary

Drug repurposing offers a promising avenue for novel stroke treatments. This review highlights existing medications with potential for new therapeutic applications in stroke care, aiming to improve patient outcomes.

Keywords:
Conventional therapyDrug developmentDrug repurposingIschemic strokeMechanical thrombectomyRecombinant-tissue plasminogen activator

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Area of Science:

  • Neuroscience and Pharmacology
  • Translational Medicine
  • Drug Discovery

Background:

  • Stroke is a leading cause of death and disability globally, with current treatments like tissue plasminogen activators (tPAs) and mechanical thrombectomy (MT) having limited therapeutic time windows.
  • Poststroke rehabilitation aids functional recovery but requires extended periods for noticeable benefits.
  • There is a critical need for expanded therapeutic strategies to address the limitations of existing stroke interventions.

Purpose of the Study:

  • To explore the potential of drug repurposing as a novel therapeutic strategy for ischemic stroke.
  • To identify and summarize marketed drugs with established safety and efficacy profiles suitable for repurposing in stroke treatment.
  • To discuss the mechanisms of action for these repurposed drugs and list those currently in clinical trials for ischemic stroke.

Main Methods:

  • Comprehensive review of existing literature on marketed drugs.
  • Analysis of safety and efficacy data for potential stroke therapeutic candidates.
  • Identification of drugs undergoing clinical trials for ischemic stroke.

Main Results:

  • Identification of several existing medications with potential for repurposing in stroke therapy.
  • Summary of the pharmacological mechanisms underlying the neuroprotective or restorative effects of these drugs.
  • Compilation of a list of repurposed drugs currently under investigation in clinical trials for ischemic stroke.

Conclusions:

  • Drug repurposing presents a viable and potentially faster approach to developing new stroke treatments compared to de novo drug discovery.
  • Repurposed drugs offer a favorable safety profile due to prior clinical use, potentially accelerating their adoption.
  • Further clinical investigation is warranted to validate the efficacy of repurposed drugs in improving outcomes for ischemic stroke patients.