Serum irisin levels increase in girls with central precocious puberty not dependent on BMI: a pilot study
Yanfei Chen1, Mei Li1, Binrong Liao1
1Department of Pediatrics, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Insights
Serum irisin levels are elevated in girls with central precocious puberty (CPP) and premature thelarche (PT). While irisin may aid in CPP diagnosis, its low sensitivity and specificity mean it cannot be used alone.
Area of Science:
- Endocrinology
- Pediatric Endocrinology
- Metabolic Research
Background:
- Irisin, a myokine, is implicated in metabolic regulation.
- Central precocious puberty (CPP) is a condition characterized by early onset of puberty.
- Understanding novel biomarkers for CPP diagnosis is crucial.
Purpose of the Study:
- To evaluate serum irisin levels as a diagnostic marker for CPP in girls.
- To identify determinants of serum irisin levels in girls with CPP.
- To assess the utility of irisin in differentiating CPP from premature thelarche (PT).
Main Methods:
- Cross-sectional study involving girls with CPP (n=67), PT (n=19), and controls (n=59).
- Multivariate linear regression (MLR) and propensity score matching (PSM) analyses were employed.
- Receiver operating characteristic (ROC) curve analysis determined the optimal irisin cutoff for CPP prediction.
Main Results:
- Girls with CPP and PT exhibited significantly higher serum irisin levels compared to controls.
- An optimal irisin cutoff of 91.88 ng/mL demonstrated 70.1% sensitivity and 72.9% specificity for CPP.
- Body Mass Index (BMI) was identified as a significant predictor of serum irisin levels.
Conclusions:
- Elevated serum irisin levels in CPP suggest its involvement in pubertal development.
- Irisin may serve as an auxiliary diagnostic indicator for CPP.
- The limited sensitivity and specificity preclude irisin's use as a standalone diagnostic tool for CPP.
Objective:
The objective of this study is to investigate the role of serum irisin level in diagnosis of central precocious puberty (CPP) in girls and its major determinants.
Methods:
This study was conducted in 67 girls with CPP, 19 girls with premature thelarche (PT) and 59 normal controls. The major determinants of irisin were assessed by multivariate linear regression (MLR) analysis. Propensity score matching (PSM) analysis was performed to minimize the bias that can result from BMI. A receiver operating characteristic curve was used to obtain the optimal threshold value of irisin.
Results:
The girls with CPP and PT had higher irisin levels than controls (P < 0.05). The optimal cutoff value of irisin levels for predicting CPP was 91.88 ng/mL, with a sensitivity of 70.1% and a specificity of 72.9%. MLR analysis showed that BMI was a predictor of irisin (P < 0.05). Serum irisin levels remained higher in the CPP girls than the controls with adjustment for BMI (P < 0.05).
Conclusions:
Increased serum irisin levels with CPP suggest that irisin is involved in puberty. However, due to low sensitivity and specificity, irisin level can only be used as an auxiliary indicator rather than a single diagnostic indicator of CPP.
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