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Looking to the future: Building New Paradigms in Comparative Physiology and Biomechanics

Craig E Franklin1, Sheila N Patek2, Patricia A Wright2

  • 1Editor-in-Chief, Journal of Experimental Biology.

The Journal of Experimental Biology
|March 8, 2022
PubMed
Abstract

No abstract available in PubMed .

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Drug clearance is a critical pharmacokinetic process involving the irreversible removal of drugs from the body through various organs over a specified time period. Physiological models are indispensable in determining organ-specific clearance, defined by the proportion of the drug eliminated per unit of time from the organ's blood volume.
The organ's clearance rate depends on the blood flow to the organ and the extraction ratio (E). The extraction ratio describes the organ's...
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