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Multiple Pulmonary Artery Plasty With Tissue-Engineered Vascular Grafts
Takashi Nagase1, Masaaki Yamagishi1, Yoshinobu Maeda1
1Department of Pediatric Cardiovascular Surgery, Children's Medical Center, and Division of Cardiovascular Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan.
The Annals of Thoracic Surgery
|March 8, 2022
Summary
Tissue-engineered vascular grafts (TEVGs) offer a promising alternative for pediatric pulmonary artery augmentation when autologous pericardium is unavailable. This study highlights successful TEVG use in complex congenital heart defect repair, demonstrating their utility in multistage surgeries.
Area of Science:
- Biomedical Engineering
- Cardiovascular Surgery
- Regenerative Medicine
Background:
- Autologous pericardium is a standard graft for pulmonary artery augmentation in pediatric cardiovascular surgery.
- Graft availability can be limited in some pediatric patients.
- Tissue-engineered vascular grafts (TEVGs) have been developed since 2014 for potential use in cardiovascular procedures.
Observation:
- A successful case of multiple pulmonary artery plasty was performed using TEVGs.
- The patient had a complex congenital heart defect: pulmonary atresia/ventricular septal defect with major aortopulmonary collateral arteries.
- This procedure involved multistage surgical interventions.
Findings:
- TEVGs proved effective for pulmonary artery reconstruction in a pediatric patient with complex congenital heart disease.
- The use of TEVGs facilitated the necessary pulmonary artery augmentation.
- Successful surgical outcomes were achieved using TEVGs in this challenging case.
Implications:
- TEVGs represent a viable and effective alternative to autologous pericardium in pediatric cardiovascular surgery.
- The application of TEVGs can be crucial in multistage surgical procedures for complex congenital heart defects.
- Further research into TEVGs could expand their role in pediatric cardiac reconstructive surgery.
