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Related Concept Videos

Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

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Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
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Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

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Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
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Pulmonary Tuberculosis IV01:26

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Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
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Pulmonary Tuberculosis II01:28

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Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
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Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

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Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
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Other Pulmonary Disorders01:17

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Respiratory disorders encompass a range of conditions with varying levels of severity. Asthma, marked by chronic airway inflammation and hypersensitivity, is one such condition. It can lead to airway obstruction due to factors like bronchial spasms, mucosal edema, increased mucus secretion, or epithelial damage. Asthma triggers are diverse, ranging from allergens to emotional upset, and treatment focuses on both immediate relief through bronchodilators and long-term inflammation suppression.
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Related Experiment Video

Updated: Oct 1, 2025

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy
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Tuberculosis in sickle cell disease patients.

A-L Houist1, C Lafont2, C Gomart3

  • 1Department of Infectious Diseases, Henri-Mondor Hospital, AP-HP, Créteil, France.

Infectious Diseases Now
|March 8, 2022
PubMed
Summary

Tuberculosis (TB) is rare in sickle cell disease (SCD) patients but carries risks. This study found TB in SCD patients is similar to others, though less infectious, suggesting specialized care aids early diagnosis.

Keywords:
Hemoglobin disordersMycobacterium tuberculosisSickle cell diseaseTuberculosis

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Area of Science:

  • Infectious Diseases
  • Hematology
  • Public Health

Background:

  • Sickle cell disease (SCD) is linked to increased bacterial infection risk.
  • Tuberculosis (TB) is infrequently reported in SCD patients.
  • High TB prevalence in populations with frequent SCD in France necessitates understanding TB in this group.

Purpose of the Study:

  • To elucidate the clinical characteristics of TB disease in adult patients with SCD.
  • To compare TB disease presentation and outcomes in SCD patients versus non-SCD patients.

Main Methods:

  • Retrospective study over 10 years at Henri-Mondor hospital's adult SCD center.
  • Included adults with SCD and positive Mycobacterium tuberculosis cultures.
  • Matched SCD patients with TB disease to non-SCD patients (1:2 ratio) for comparison.

Main Results:

  • Twelve SCD patients with TB disease (median age 29) were compared to 24 non-SCD patients (median age 33).
  • Pulmonary TB was predominant in SCD patients (10/12).
  • SCD patients showed fewer positive sputum smears and lung cavitations, indicating potentially lower infectiousness.

Conclusions:

  • TB disease in SCD patients shares similarities with non-SCD patients.
  • SCD patients with TB appear less infectious.
  • Regular follow-up in specialized centers may facilitate earlier TB diagnosis in SCD patients.