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Protrusion Force Microscopy: A Method to Quantify Forces Developed by Cell Protrusions
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Removal of cellular protrusions.

Mayu Inaba1, Sharif M Ridwan1, Matthew Antel1

  • 1Department of Cell Biology, University of Connecticut Health Center, Farmington, CT 06030, USA.

Seminars in Cell & Developmental Biology
|March 9, 2022
PubMed
Summary
This summary is machine-generated.

Cellular protrusions like cilia and nanotubes are vital for cell communication. Their removal regulates signaling strength and patterns, offering new insights into physiological and pathological processes.

Keywords:
CiliaEctocytosisMicrotubule-based (MT)-nanotubesNeurite pruningPhagocytosisSignaling protrusionTrogocytosis

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Area of Science:

  • Cell Biology
  • Molecular Biology
  • Physiology

Background:

  • Cell-cell communication is crucial for multicellular organisms, often mediated by specialized cellular protrusions.
  • Recent advances in imaging have improved the identification of these signaling structures.
  • Physical regulation of protrusions is key for effective cell signaling.

Purpose of the Study:

  • To review studies on the removal of various signaling protrusions.
  • To discuss the mechanisms and significance of protrusion removal in signaling regulation.

Main Methods:

  • Literature review of studies on cellular protrusions.
  • Analysis of mechanisms for protrusion removal.
  • Discussion of the role of protrusion removal in cell signaling.

Main Results:

  • Identified various signaling protrusions: cilia, neurites, microtubule (MT)-based nanotubes, and microvilli.
  • Summarized mechanisms involved in the removal of these structures.
  • Highlighted the importance of protrusion removal in regulating cell signaling outcomes.

Conclusions:

  • The removal of signaling protrusions is a significant mechanism for regulating cell-cell communication.
  • Understanding these removal processes is essential for comprehending both normal physiological functions and pathological conditions.