Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Natural Selection and Adaptation01:15

Natural Selection and Adaptation

721
Natural selection, a fundamental concept in evolutionary biology, is the mechanism by which evolution is driven, favoring organisms that are best adapted to their environments. This process enhances their chances of survival and reproduction. Adaptation, a key outcome of this process, involves genetic modifications that optimize an organism's functionality under specific environmental challenges, such as extreme cold or thinner air at high altitudes.
Beyond physical adaptations,...
721
Leveling Equipment01:18

Leveling Equipment

163
As leveling involves measuring vertical distances relative to a horizontal line of sight, it requires a graduated rod, called a level rod, for vertical measurements and an instrument called a level for a horizontal sight line. A level includes a high-powered telescope with a mechanism for leveling to ensure the line of sight is horizontal when the bubble in the spirit level is centered. Leveling rods, made of wood, metal, or fiberglass, are graduated in feet or meters and commonly used in two-...
163
Frictional Forces on Screws01:17

Frictional Forces on Screws

1.3K
Screws are characterized by a helical ridge known as a thread wrapped around a cylindrical shaft. They are commonly used as fasteners to hold objects together or to transmit power and motion in machines. One type of screw that is particularly useful for transmitting power is the square-threaded screw.
A jack with a square-threaded screw is a mechanical device used to lift heavy loads by applying a force at its handle. When the force is applied, the screw turns, raising the load. The screw can...
1.3K
Toughness and Hardness of Aggregate01:22

Toughness and Hardness of Aggregate

362
Toughness and hardness are critical properties of aggregate materials used in concrete, particularly on pavement surfaces and industrial flooring subjected to heavy loads. Toughness is defined as the aggregate's resistance to failure by impact and is measured by the aggregate impact value (AIV). For this, the aggregate impact value test is performed, wherein the impact is delivered by a standard hammer, which falls freely under its own weight onto the aggregates. The aggregates fragment in...
362
Prismatic Beams: Problem Solving01:15

Prismatic Beams: Problem Solving

232
In the design of a supported timber beam subjected to a distributed load, both the beam's physical dimensions and the timber's characteristics, such as its grade and species, are critical. These factors determine the allowable stress values, which are crucial for calculating the necessary beam depth to ensure structural integrity and safety.
The design begins with analyzing the beam as a free body to identify moments and force balances, thereby determining support reactions. Next, the...
232
Limits to Natural Selection01:38

Limits to Natural Selection

32.7K
Organisms that are well-adapted to their environment are more likely to survive and reproduce. However, natural selection does not lead to perfectly adapted organisms. Several factors constrain natural selection.
32.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparative Efficacy of Non-opioid Analgesic Drugs for Chronic Cancer Pain: A Bayesian Network Meta-analysis.

Drugs·2026
Same author

Oropharyngeal Dysphagia as a Metabolic Emergency: A Comprehensive Review on Nutritional Barriers, Sarcopenia, and Management Strategies.

Nutrients·2026
Same author

Response to dual anti-impulse and lipid-lowering therapy is associated with clinical outcomes in chronic type B aortic syndrome.

Internal and emergency medicine·2026
Same author

Management of Nonmedical Use of Prescribed Pharmaceutical Fentanyl Products in an Acute Palliative Care Unit: A Case Series.

Journal of palliative medicine·2026
Same author

Age differences in symptom burden of patients with advanced cancer admitted to an acute palliative care unit.

Internal and emergency medicine·2026
Same author

Comprehensive Palliative Care in Patients with Lung Cancer Admitted to an Acute Palliative Care Unit.

Cancers·2026

Related Experiment Video

Updated: Oct 1, 2025

Author Spotlight: Development of an Automated Camera-Based System for Real-Time Blast Overpressure Monitoring and TBI Risk Assessment in Military Training
06:20

Author Spotlight: Development of an Automated Camera-Based System for Real-Time Blast Overpressure Monitoring and TBI Risk Assessment in Military Training

Published on: December 6, 2024

3.0K

When the game is hard, more complex weapons are needed.

Sebastiano Mercadante1,2, Claudio Adile3, Patrizia Ferrera3

  • 1Pain relief and supportive care, La Maddalena, Palermo, Italy terapiadeldolore@lamaddalenanet.it.

BMJ Supportive & Palliative Care
|March 9, 2022
PubMed
Summary
This summary is machine-generated.

Managing severe pain requires expert clinical judgment and adaptive strategies. This case study highlights a step-by-step approach to complex pain management when standard treatments fail.

Keywords:
cancerhospice carepainpharmacologysupportive careterminal care

More Related Videos

Combining Computer Game-Based Behavioural Experiments With High-Density EEG and Infrared Gaze Tracking
13:40

Combining Computer Game-Based Behavioural Experiments With High-Density EEG and Infrared Gaze Tracking

Published on: December 16, 2010

16.8K
Conducting Elevated Temperature Normal and Combined Pressure-Shear Plate Impact Experiments Via a Breech-end Sabot Heater System
10:52

Conducting Elevated Temperature Normal and Combined Pressure-Shear Plate Impact Experiments Via a Breech-end Sabot Heater System

Published on: August 7, 2018

8.7K

Related Experiment Videos

Last Updated: Oct 1, 2025

Author Spotlight: Development of an Automated Camera-Based System for Real-Time Blast Overpressure Monitoring and TBI Risk Assessment in Military Training
06:20

Author Spotlight: Development of an Automated Camera-Based System for Real-Time Blast Overpressure Monitoring and TBI Risk Assessment in Military Training

Published on: December 6, 2024

3.0K
Combining Computer Game-Based Behavioural Experiments With High-Density EEG and Infrared Gaze Tracking
13:40

Combining Computer Game-Based Behavioural Experiments With High-Density EEG and Infrared Gaze Tracking

Published on: December 16, 2010

16.8K
Conducting Elevated Temperature Normal and Combined Pressure-Shear Plate Impact Experiments Via a Breech-end Sabot Heater System
10:52

Conducting Elevated Temperature Normal and Combined Pressure-Shear Plate Impact Experiments Via a Breech-end Sabot Heater System

Published on: August 7, 2018

8.7K

Area of Science:

  • Pain Management
  • Clinical Case Study

Background:

  • Managing difficult pain conditions presents significant clinical challenges.
  • Standard analgesic regimens may be insufficient for complex pain syndromes.

Purpose of the Study:

  • To illustrate a complex management strategy for a severe pain condition.
  • To demonstrate an adaptive approach to challenging pain situations.

Main Methods:

  • A clinical case note detailing a multi-modal analgesic approach.
  • Involved opioid dose titration, substitution attempts, and spinal analgesia.

Main Results:

  • Opioid dose titration and substitution were ultimately unsuccessful.
  • Spinal analgesia provided prolonged pain relief, requiring ongoing adjustments.
  • The clinical situation evolved, necessitating continuous interventions.

Conclusions:

  • Effective management of extreme pain requires extensive expertise and knowledge.
  • Complex strategies must be developed iteratively as the pain syndrome worsens.
  • Treatment necessitates continuous clinical adaptation to evolving conditions rather than fixed recommendations.