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Prevalence, distribution and correlates of pain in patients with mucormycosis-A cross-sectional study

Milon V Mitragotri1, Roopa Sachidananda1, Mahesh D Kurugodiyavar2

  • 1Department of Anaesthesiology, Karnataka Institute of Medical Sciences, Hubli, Karnataka, India.

Saudi Journal of Anaesthesia
|March 9, 2022
PubMed
Abstract

Insights

Pain is a common symptom in rhino-orbital-cerebral mucormycosis patients, often presenting as throbbing pain in the supraorbital region. This study highlights pain as a key indicator in mucormycosis cases.

Area of Science:

  • Medical Mycology
  • Infectious Diseases
  • Pain Management

Background:

  • Rhino-orbital-cerebral mucormycosis (ROC) cases surged in India, particularly post-COVID-19.
  • Limited understanding of ROC epidemiology and symptomatology existed prior to this study.

Purpose of the Study:

  • To determine the prevalence of pain in patients diagnosed with mucormycosis.
  • To characterize the type, location, and determinants of pain in mucormycosis patients.

Main Methods:

  • A cross-sectional study involving adult patients with mucormycosis.
  • Data collected via a pre-tested, closed-ended questionnaire administered during a single visit.

Main Results:

  • 69 out of 80 patients (86.25%) reported pain.
  • Supraorbital pain was most common (76.8%), often throbbing (84%) and requiring analgesics (98.6%).
  • Pain presence/severity was not influenced by gender, diabetes, affected organs, steroid use, COVID-19 history, surgery, or prior pain.

Conclusions:

  • Pain is a significant presenting symptom in mucormycosis, typically located in the supraorbital/maxillary regions.
  • The pain is characterized as nociceptive, throbbing, and moderate to severe.
  • Simple analgesics are generally effective for managing mucormycosis-related pain.
Keywords:
COVID19The majority of the patients recruited in our study had supraorbital or maxillary region pain of moderate to severe intensity signifying probably the parallel involvement of these sinuses by mucormycosis. Hence, the clinician should have a high degree of suspicion of mucormycosis if patients with pain present with such manifestationmucormycosispain

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